Antigen presentation

Détails

ID Serval
serval:BIB_DC05DC600C11
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Antigen presentation
Périodique
FASEB Journal
Auteur(s)
Unanue  E. R., Cerottini  J. C.
ISSN
0892-6638 (Print)
Statut éditorial
Publié
Date de publication
11/1989
Volume
3
Numéro
13
Pages
2496-502
Notes
Journal Article
Review --- Old month value: Nov
Résumé
This paper reviews some of the cellular events involved in the immune recognition of foreign proteins. The recognition of an antigen by T lymphocytes is essential for its effective elimination by the host. T lymphocytes of the CD4 or CD8 subset recognize antigen but only after the antigen is handled by antigen-handling cells (antigen-presenting cells). Antigen molecules are recognized after an internal processing event by antigen-presenting cells that results in the generation of immunogenic peptides. Such peptides associate with histocompatibility molecules to form bimolecular complexes on the cell surface. The T cell receptors for antigen recognize the bimolecular complex and initiate the events that result in an inflammatory response. Antigen-presenting cells also produce molecules - termed costimulators - that stimulate the growth and differentiation of T lymphocytes.
Mots-clé
Animals Antigen-Presenting Cells/*immunology Antigens/*immunology CD4-Positive T-Lymphocytes/immunology Histocompatibility Antigens/immunology T-Lymphocytes, Cytotoxic/immunology T-Lymphocytes, Helper-Inducer/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 11:13
Dernière modification de la notice
20/08/2019 16:00
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