Antigen presentation

Details

Serval ID
serval:BIB_DC05DC600C11
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Antigen presentation
Journal
FASEB Journal
Author(s)
Unanue  E. R., Cerottini  J. C.
ISSN
0892-6638 (Print)
Publication state
Published
Issued date
11/1989
Volume
3
Number
13
Pages
2496-502
Notes
Journal Article
Review --- Old month value: Nov
Abstract
This paper reviews some of the cellular events involved in the immune recognition of foreign proteins. The recognition of an antigen by T lymphocytes is essential for its effective elimination by the host. T lymphocytes of the CD4 or CD8 subset recognize antigen but only after the antigen is handled by antigen-handling cells (antigen-presenting cells). Antigen molecules are recognized after an internal processing event by antigen-presenting cells that results in the generation of immunogenic peptides. Such peptides associate with histocompatibility molecules to form bimolecular complexes on the cell surface. The T cell receptors for antigen recognize the bimolecular complex and initiate the events that result in an inflammatory response. Antigen-presenting cells also produce molecules - termed costimulators - that stimulate the growth and differentiation of T lymphocytes.
Keywords
Animals Antigen-Presenting Cells/*immunology Antigens/*immunology CD4-Positive T-Lymphocytes/immunology Histocompatibility Antigens/immunology T-Lymphocytes, Cytotoxic/immunology T-Lymphocytes, Helper-Inducer/immunology
Pubmed
Web of science
Create date
28/01/2008 11:13
Last modification date
20/08/2019 16:00
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