Antigen presentation
Details
Serval ID
serval:BIB_DC05DC600C11
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Antigen presentation
Journal
FASEB Journal
ISSN
0892-6638 (Print)
Publication state
Published
Issued date
11/1989
Volume
3
Number
13
Pages
2496-502
Notes
Journal Article
Review --- Old month value: Nov
Review --- Old month value: Nov
Abstract
This paper reviews some of the cellular events involved in the immune recognition of foreign proteins. The recognition of an antigen by T lymphocytes is essential for its effective elimination by the host. T lymphocytes of the CD4 or CD8 subset recognize antigen but only after the antigen is handled by antigen-handling cells (antigen-presenting cells). Antigen molecules are recognized after an internal processing event by antigen-presenting cells that results in the generation of immunogenic peptides. Such peptides associate with histocompatibility molecules to form bimolecular complexes on the cell surface. The T cell receptors for antigen recognize the bimolecular complex and initiate the events that result in an inflammatory response. Antigen-presenting cells also produce molecules - termed costimulators - that stimulate the growth and differentiation of T lymphocytes.
Keywords
Animals
Antigen-Presenting Cells/*immunology
Antigens/*immunology
CD4-Positive T-Lymphocytes/immunology
Histocompatibility Antigens/immunology
T-Lymphocytes, Cytotoxic/immunology
T-Lymphocytes, Helper-Inducer/immunology
Pubmed
Web of science
Create date
28/01/2008 12:13
Last modification date
20/08/2019 17:00