Tomographic in vivo microscopy for the study of lung physiology at the alveolar level.

Détails

Ressource 1Télécharger: 28970505_BIB_DB03D8E933E8.pdf (5714.07 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_DB03D8E933E8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Tomographic in vivo microscopy for the study of lung physiology at the alveolar level.
Périodique
Scientific reports
Auteur⸱e⸱s
Lovric G., Mokso R., Arcadu F., Vogiatzis Oikonomidis I., Schittny J.C., Roth-Kleiner M., Stampanoni M.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
02/10/2017
Peer-reviewed
Oui
Volume
7
Numéro
1
Pages
12545
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Lungs represent the essential part of the mammalian respiratory system, which is reflected in the fact that lung failure still is one of the leading causes of morbidity and mortality worldwide. Establishing the connection between macroscopic observations of inspiration and expiration and the processes taking place at the microscopic scale remains crucial to understand fundamental physiological and pathological processes. Here we demonstrate for the first time in vivo synchrotron-based tomographic imaging of lungs with pixel sizes down to a micrometer, enabling first insights into high-resolution lung structure. We report the methodological ability to study lung inflation patterns at the alveolar scale and its potential in resolving still open questions in lung physiology. As a first application, we identified heterogeneous distension patterns at the alveolar level and assessed first comparisons of lungs between the in vivo and immediate post mortem states.
Mots-clé
Animals, Autopsy, Humans, Intravital Microscopy/methods, Lung/diagnostic imaging, Lung/physiopathology, Lung/ultrastructure, Pulmonary Alveoli/diagnostic imaging, Pulmonary Alveoli/ultrastructure, Rats, Respiratory Distress Syndrome, Adult/diagnostic imaging, Respiratory Distress Syndrome, Adult/physiopathology, Respiratory Physiological Phenomena, Tomography, X-Ray Computed/methods
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/10/2017 13:34
Dernière modification de la notice
21/11/2022 8:30
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