Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies.

Détails

ID Serval
serval:BIB_DAFBA2EF4915
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies.
Périodique
Molecular therapy
Auteur⸱e⸱s
Leroux E., Perbet R., Caillierez R., Richetin K., Lieger S., Espourteille J., Bouillet T., Bégard S., Danis C., Loyens A., Toni N., Déglon N., Deramecourt V., Schraen-Maschke S., Buée L., Colin M.
ISSN
1525-0024 (Electronic)
ISSN-L
1525-0016
Statut éditorial
Publié
Date de publication
02/02/2022
Peer-reviewed
Oui
Volume
30
Numéro
2
Pages
782-797
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Tauopathies are neurodegenerative diseases characterized by tau inclusions in brain cells. Seed-competent tau species have been suggested to spread from cell to cell in a stereotypical manner, indicating that this may involve a prion-like mechanism. Although the intercellular mechanisms of transfer are unclear, extracellular vesicles (EVs) could be potential shuttles. We assessed this in humans by preparing vesicles from fluids (brain-derived enriched EVs [BD-EVs]). These latter were isolated from different brain regions in various tauopathies, and their seeding potential was assessed in vitro and in vivo. We observed considerable heterogeneity among tauopathies and brain regions. The most striking evidence was coming mainly from Alzheimer's disease where the BD-EVs clearly contain pathological species that can induce tau lesions in vivo. The results support the hypothesis that BD-EVs participate in the prion-like propagation of tau pathology among tauopathies, and there may be implications for diagnostic and therapeutic strategies.
Mots-clé
Alzheimer Disease/genetics, Alzheimer Disease/pathology, Brain/metabolism, Extracellular Vesicles/metabolism, Humans, Tauopathies/genetics, Tauopathies/pathology, tau Proteins/genetics, tau Proteins/metabolism, Alzheimer’s disease, biological fluids, exosomes, microvesicles, prion-like propagation, seeding, tauopathies
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/09/2021 13:06
Dernière modification de la notice
26/04/2022 6:37
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