Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between plasma drug levels and the renin angiotensin system

Détails

ID Serval
serval:BIB_D9807194974D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between plasma drug levels and the renin angiotensin system
Périodique
British Journal of Clinical Pharmacology
Auteur⸱e⸱s
Biollaz  J., Schelling  J. L., Jacot Des Combes  B., Brunner  D. B., Desponds  G., Brunner  H. R., Ulm  E. H., Hichens  M., Gomez  H. J.
ISSN
0306-5251 (Print)
Statut éditorial
Publié
Date de publication
09/1982
Volume
14
Numéro
3
Pages
363-8
Notes
Journal Article --- Old month value: Sep
Résumé
1 Two single doses of 10 mg each of the converting enzyme inhibitor enalapril maleate or MK-421 and of its lysine analogue (MK-521) were administered p.o. to twelve male volunteers. 2 The active diacid metabolite of MK-421 and the lysine analogue were determined by radioimmunoassay and MK-421 by the active metabolite method following in vitro hydrolysis. 3 Peak serum levels of MK-421, active metabolite and lysine analogue were reached within 1, 3 to 4, and 6 h respectively. Practically all MK-421 had disappeared from serum within 4 h. 4 A close correlation between percent inhibition of plasma converting enzyme activity and the serum concentration of active metabolite was observed ( r = 0.98, n = 171, P less than 0.001). Similarly, converting enzyme blockade as expressed by the ratio plasma angiotensin II/angiotensin I was closely correlated with serum active metabolite levels (r = 0.93, n = 15, P less than 0.001).
Mots-clé
Adult *Angiotensin-Converting Enzyme Inhibitors Angiotensins/blood Captopril/pharmacology Dipeptides/*blood/pharmacology Enalapril Humans Lisinopril Male Renin-Angiotensin System/*drug effects
Pubmed
Web of science
Création de la notice
25/01/2008 10:40
Dernière modification de la notice
20/08/2019 15:58
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