Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between plasma drug levels and the renin angiotensin system
Détails
ID Serval
serval:BIB_D9807194974D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between plasma drug levels and the renin angiotensin system
Périodique
British Journal of Clinical Pharmacology
ISSN
0306-5251 (Print)
Statut éditorial
Publié
Date de publication
09/1982
Volume
14
Numéro
3
Pages
363-8
Notes
Journal Article --- Old month value: Sep
Résumé
1 Two single doses of 10 mg each of the converting enzyme inhibitor enalapril maleate or MK-421 and of its lysine analogue (MK-521) were administered p.o. to twelve male volunteers. 2 The active diacid metabolite of MK-421 and the lysine analogue were determined by radioimmunoassay and MK-421 by the active metabolite method following in vitro hydrolysis. 3 Peak serum levels of MK-421, active metabolite and lysine analogue were reached within 1, 3 to 4, and 6 h respectively. Practically all MK-421 had disappeared from serum within 4 h. 4 A close correlation between percent inhibition of plasma converting enzyme activity and the serum concentration of active metabolite was observed ( r = 0.98, n = 171, P less than 0.001). Similarly, converting enzyme blockade as expressed by the ratio plasma angiotensin II/angiotensin I was closely correlated with serum active metabolite levels (r = 0.93, n = 15, P less than 0.001).
Mots-clé
Adult
*Angiotensin-Converting Enzyme Inhibitors
Angiotensins/blood
Captopril/pharmacology
Dipeptides/*blood/pharmacology
Enalapril
Humans
Lisinopril
Male
Renin-Angiotensin System/*drug effects
Pubmed
Web of science
Création de la notice
25/01/2008 11:40
Dernière modification de la notice
20/08/2019 16:58