Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between plasma drug levels and the renin angiotensin system

Details

Serval ID
serval:BIB_D9807194974D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between plasma drug levels and the renin angiotensin system
Journal
British Journal of Clinical Pharmacology
Author(s)
Biollaz  J., Schelling  J. L., Jacot Des Combes  B., Brunner  D. B., Desponds  G., Brunner  H. R., Ulm  E. H., Hichens  M., Gomez  H. J.
ISSN
0306-5251 (Print)
Publication state
Published
Issued date
09/1982
Volume
14
Number
3
Pages
363-8
Notes
Journal Article --- Old month value: Sep
Abstract
1 Two single doses of 10 mg each of the converting enzyme inhibitor enalapril maleate or MK-421 and of its lysine analogue (MK-521) were administered p.o. to twelve male volunteers. 2 The active diacid metabolite of MK-421 and the lysine analogue were determined by radioimmunoassay and MK-421 by the active metabolite method following in vitro hydrolysis. 3 Peak serum levels of MK-421, active metabolite and lysine analogue were reached within 1, 3 to 4, and 6 h respectively. Practically all MK-421 had disappeared from serum within 4 h. 4 A close correlation between percent inhibition of plasma converting enzyme activity and the serum concentration of active metabolite was observed ( r = 0.98, n = 171, P less than 0.001). Similarly, converting enzyme blockade as expressed by the ratio plasma angiotensin II/angiotensin I was closely correlated with serum active metabolite levels (r = 0.93, n = 15, P less than 0.001).
Keywords
Adult *Angiotensin-Converting Enzyme Inhibitors Angiotensins/blood Captopril/pharmacology Dipeptides/*blood/pharmacology Enalapril Humans Lisinopril Male Renin-Angiotensin System/*drug effects
Pubmed
Web of science
Create date
25/01/2008 10:40
Last modification date
20/08/2019 15:58
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