Invasive aspergillosis in solid organ transplant patients: diagnosis, prophylaxis, treatment, and assessment of response.

Détails

ID Serval
serval:BIB_D96B6F63A459
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Invasive aspergillosis in solid organ transplant patients: diagnosis, prophylaxis, treatment, and assessment of response.
Périodique
BMC infectious diseases
Auteur(s)
Neofytos D., Garcia-Vidal C., Lamoth F., Lichtenstern C., Perrella A., Vehreschild J.J.
ISSN
1471-2334 (Electronic)
ISSN-L
1471-2334
Statut éditorial
Publié
Date de publication
24/03/2021
Peer-reviewed
Oui
Volume
21
Numéro
1
Pages
296
Langue
anglais
Notes
Publication types: Letter
Publication Status: epublish
Résumé
Invasive aspergillosis (IA) is a rare complication in solid organ transplant (SOT) recipients. Although IA has significant implications on graft and patient survival, data on diagnosis and management of this infection in SOT recipients are still limited.
Discussion of current practices and limitations in the diagnosis, prophylaxis, and treatment of IA and proposal of means of assessing treatment response in SOT recipients.
Liver, lung, heart or kidney transplant recipients have common as well as different risk factors to the development of IA, thus each category needs a separate evaluation. Diagnosis of IA in SOT recipients requires a high degree of awareness, because established diagnostic tools may not provide the same sensitivity and specificity observed in the neutropenic population. IA treatment relies primarily on mold-active triazoles, but potential interactions with immunosuppressants and other concomitant therapies need special attention.
Criteria to assess response have not been sufficiently evaluated in the SOT population and CT lesion dynamics, and serologic markers may be influenced by the underlying disease and type and severity of immunosuppression. There is a need for well-orchestrated efforts to study IA diagnosis and management in SOT recipients and to develop comprehensive guidelines for this population.
Mots-clé
Aspergillosis/diagnosis, Aspergillosis/drug therapy, Aspergillosis/etiology, Aspergillosis/prevention & control, Humans, Immunosuppression/adverse effects, Immunosuppressive Agents/therapeutic use, Invasive Fungal Infections/diagnosis, Invasive Fungal Infections/drug therapy, Invasive Fungal Infections/etiology, Invasive Fungal Infections/prevention & control, Organ Transplantation/adverse effects, Patient Outcome Assessment, Practice Guidelines as Topic, Transplant Recipients, Triazoles/therapeutic use, Aspergillus, Invasive pulmonary aspergillosis, Microbiome, Mucorales, Mucormycosis, Solid organ transplantation
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/04/2021 9:46
Dernière modification de la notice
08/06/2021 5:37
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