Invasive aspergillosis in solid organ transplant patients: diagnosis, prophylaxis, treatment, and assessment of response.

Details

Serval ID
serval:BIB_D96B6F63A459
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Invasive aspergillosis in solid organ transplant patients: diagnosis, prophylaxis, treatment, and assessment of response.
Journal
BMC infectious diseases
Author(s)
Neofytos D., Garcia-Vidal C., Lamoth F., Lichtenstern C., Perrella A., Vehreschild J.J.
ISSN
1471-2334 (Electronic)
ISSN-L
1471-2334
Publication state
Published
Issued date
24/03/2021
Peer-reviewed
Oui
Volume
21
Number
1
Pages
296
Language
english
Notes
Publication types: Letter
Publication Status: epublish
Abstract
Invasive aspergillosis (IA) is a rare complication in solid organ transplant (SOT) recipients. Although IA has significant implications on graft and patient survival, data on diagnosis and management of this infection in SOT recipients are still limited.
Discussion of current practices and limitations in the diagnosis, prophylaxis, and treatment of IA and proposal of means of assessing treatment response in SOT recipients.
Liver, lung, heart or kidney transplant recipients have common as well as different risk factors to the development of IA, thus each category needs a separate evaluation. Diagnosis of IA in SOT recipients requires a high degree of awareness, because established diagnostic tools may not provide the same sensitivity and specificity observed in the neutropenic population. IA treatment relies primarily on mold-active triazoles, but potential interactions with immunosuppressants and other concomitant therapies need special attention.
Criteria to assess response have not been sufficiently evaluated in the SOT population and CT lesion dynamics, and serologic markers may be influenced by the underlying disease and type and severity of immunosuppression. There is a need for well-orchestrated efforts to study IA diagnosis and management in SOT recipients and to develop comprehensive guidelines for this population.
Keywords
Aspergillosis/diagnosis, Aspergillosis/drug therapy, Aspergillosis/etiology, Aspergillosis/prevention & control, Humans, Immunosuppression/adverse effects, Immunosuppressive Agents/therapeutic use, Invasive Fungal Infections/diagnosis, Invasive Fungal Infections/drug therapy, Invasive Fungal Infections/etiology, Invasive Fungal Infections/prevention & control, Organ Transplantation/adverse effects, Patient Outcome Assessment, Practice Guidelines as Topic, Transplant Recipients, Triazoles/therapeutic use, Aspergillus, Invasive pulmonary aspergillosis, Microbiome, Mucorales, Mucormycosis, Solid organ transplantation
Pubmed
Web of science
Open Access
Yes
Create date
05/04/2021 10:46
Last modification date
08/06/2021 6:37
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