Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
Détails
ID Serval
serval:BIB_D8FE45B42414
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
1988
Volume
85
Numéro
19
Pages
7159-7163
Langue
anglais
Résumé
The cDNA for the Syrian hamster alpha 1-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the receptor protein purified from DDT1MF-2 smooth muscle cells. The deduced amino acid sequence encodes a 515-residue polypeptide that shows the most sequence identity with the other adrenergic receptors and the putative protein product of the related clone G-21. Similarities with the muscarinic cholinergic receptors are also evident. Expression studies in COS-7 cells confirm that we have cloned the alpha 1-adrenergic receptor that couples to inositol phospholipid metabolism.
Mots-clé
Animals, Base Sequence, Cloning, Molecular, Cricetinae, DNA/analysis, GTP-Binding Proteins/metabolism, Gene Expression Regulation, Molecular Sequence Data, Phosphatidylinositols/metabolism, Receptors, Adrenergic, alpha/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 12:05
Dernière modification de la notice
20/08/2019 16:58