Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

Détails

ID Serval
serval:BIB_D8FE45B42414
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Cotecchia S., Schwinn D.A., Randall R.R., Lefkowitz R.J., Caron M.G., Kobilka B.K.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
1988
Volume
85
Numéro
19
Pages
7159-7163
Langue
anglais
Résumé
The cDNA for the Syrian hamster alpha 1-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the receptor protein purified from DDT1MF-2 smooth muscle cells. The deduced amino acid sequence encodes a 515-residue polypeptide that shows the most sequence identity with the other adrenergic receptors and the putative protein product of the related clone G-21. Similarities with the muscarinic cholinergic receptors are also evident. Expression studies in COS-7 cells confirm that we have cloned the alpha 1-adrenergic receptor that couples to inositol phospholipid metabolism.
Mots-clé
Animals, Base Sequence, Cloning, Molecular, Cricetinae, DNA/analysis, GTP-Binding Proteins/metabolism, Gene Expression Regulation, Molecular Sequence Data, Phosphatidylinositols/metabolism, Receptors, Adrenergic, alpha/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 12:05
Dernière modification de la notice
09/05/2019 1:59
Données d'usage