Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_D8ECE281A973
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support.
Périodique
Frontiers in pediatrics
Auteur⸱e⸱s
Pérez Marín M., Prod'hom S., de Villiers S.F., Ferry T., Amiet V., Natterer J., Perez M.H., Buclin T., Chtioui H. (co-dernier), Longchamp D.
ISSN
2296-2360 (Print)
ISSN-L
2296-2360
Statut éditorial
Publié
Date de publication
2021
Peer-reviewed
Oui
Volume
9
Pages
658347
Langue
anglais
Notes
Publication types: Case Reports
Publication Status: epublish
Résumé
Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal. At therapeutic concentrations, colchicine elimination occurs mainly through hepatic metabolism and involves an enterohepatic circulation, with a small contribution of renal elimination (10-30%). Colchicine toxicokinetics is however rarely described, especially in children. We present the case of a 4-year-old patient who survived a severe iatrogenic colchicine intoxication with a dose of 0.5 mg/kg. She developed multi-organ failure and shock, but recovered after receiving aggressive resuscitation, including extracorporeal life support. Close monitoring of colchicine blood levels showed a plateau for 6 days, indicating impeded elimination resulting from liver failure. We observed no significant clearance from renal replacement therapy, nor activated charcoal, during this period. Extracorporeal life support may play a supportive role in the management of severe colchicine poisoning. However, extracorporeal techniques do not seem to improve colchicine elimination.
Mots-clé
ECMO, case report, colchicine poisoning, pediatric, toxicokinetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/05/2021 11:54
Dernière modification de la notice
21/11/2022 8:21
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