Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support.

Details

Serval ID
serval:BIB_D8ECE281A973
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support.
Journal
Frontiers in pediatrics
Author(s)
Pérez Marín M., Prod'hom S., de Villiers S.F., Ferry T., Amiet V., Natterer J., Perez M.H., Buclin T., Chtioui H. (co-last), Longchamp D.
ISSN
2296-2360 (Print)
ISSN-L
2296-2360
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
9
Pages
658347
Language
english
Notes
Publication types: Case Reports
Publication Status: epublish
Abstract
Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal. At therapeutic concentrations, colchicine elimination occurs mainly through hepatic metabolism and involves an enterohepatic circulation, with a small contribution of renal elimination (10-30%). Colchicine toxicokinetics is however rarely described, especially in children. We present the case of a 4-year-old patient who survived a severe iatrogenic colchicine intoxication with a dose of 0.5 mg/kg. She developed multi-organ failure and shock, but recovered after receiving aggressive resuscitation, including extracorporeal life support. Close monitoring of colchicine blood levels showed a plateau for 6 days, indicating impeded elimination resulting from liver failure. We observed no significant clearance from renal replacement therapy, nor activated charcoal, during this period. Extracorporeal life support may play a supportive role in the management of severe colchicine poisoning. However, extracorporeal techniques do not seem to improve colchicine elimination.
Keywords
ECMO, case report, colchicine poisoning, pediatric, toxicokinetics
Pubmed
Web of science
Open Access
Yes
Create date
03/05/2021 12:54
Last modification date
22/05/2021 6:33
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