Effects of nephrectomy on renal salt and water transport in the remaining kidney
Détails
ID Serval
serval:BIB_D81B65BB2C66
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of nephrectomy on renal salt and water transport in the remaining kidney
Périodique
Kidney International
ISSN
0085-2538
Statut éditorial
Publié
Date de publication
12/1976
Peer-reviewed
Oui
Volume
10
Numéro
6
Pages
450-62
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec
Résumé
Fluid, sodium, and potassium transport was studied in proximal and distal tubules in rats in which one kidney had been removed two weeks after a suprarenal aortic clamp had been placed to prevent adaptive changes in glomerular filtration rate (GFR) in the experimental kidney. Free-flow micropuncture techniques were used and tubular fluid (TF) samples analyzed for inulin, sodium and potassium. In addition, peritubular total protein concentrations and luminal and peritubular hydrostatic pressures were measured. The following changes were observed 15 hr after unilateral nephrectomy: (1) a significant increase in single nephron GFR; (2) unchanged absolute proximal tubular reabsorption rates of fluid and sodium; (3) increased delivery of fluid into distal tubules; (4) increased distal tubular reabsorption of sodium, but of insufficient magnitude to prevent natriuresis; and (5) an augmentation of distal tubular potassium secretion. Reduction of single nephron GRF to control levels by aortic clamping abolished the natriuresis following nephrectomy.
Mots-clé
Animals
Blood Pressure
Glomerular Filtration Rate
Hydrostatic Pressure
Insulin/metabolism
Kidney/blood supply/*physiology
Kidney Tubules/metabolism
Male
Natriuresis
*Nephrectomy
Nephrons/metabolism
Potassium/*urine
Rats
Renal Artery
Sodium/*metabolism
Time Factors
Water/*metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2008 12:54
Dernière modification de la notice
20/08/2019 16:57