Effects of nephrectomy on renal salt and water transport in the remaining kidney

Details

Serval ID
serval:BIB_D81B65BB2C66
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of nephrectomy on renal salt and water transport in the remaining kidney
Journal
Kidney International
Author(s)
Diezi  J., Michoud  P., Grandchamp  A., Giebisch  G.
ISSN
0085-2538
Publication state
Published
Issued date
12/1976
Peer-reviewed
Oui
Volume
10
Number
6
Pages
450-62
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec
Abstract
Fluid, sodium, and potassium transport was studied in proximal and distal tubules in rats in which one kidney had been removed two weeks after a suprarenal aortic clamp had been placed to prevent adaptive changes in glomerular filtration rate (GFR) in the experimental kidney. Free-flow micropuncture techniques were used and tubular fluid (TF) samples analyzed for inulin, sodium and potassium. In addition, peritubular total protein concentrations and luminal and peritubular hydrostatic pressures were measured. The following changes were observed 15 hr after unilateral nephrectomy: (1) a significant increase in single nephron GFR; (2) unchanged absolute proximal tubular reabsorption rates of fluid and sodium; (3) increased delivery of fluid into distal tubules; (4) increased distal tubular reabsorption of sodium, but of insufficient magnitude to prevent natriuresis; and (5) an augmentation of distal tubular potassium secretion. Reduction of single nephron GRF to control levels by aortic clamping abolished the natriuresis following nephrectomy.
Keywords
Animals Blood Pressure Glomerular Filtration Rate Hydrostatic Pressure Insulin/metabolism Kidney/blood supply/*physiology Kidney Tubules/metabolism Male Natriuresis *Nephrectomy Nephrons/metabolism Potassium/*urine Rats Renal Artery Sodium/*metabolism Time Factors Water/*metabolism
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2008 11:54
Last modification date
20/08/2019 15:57
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