Pineal parenchymal tumors of intermediate differentiation in adults: case report and literature review.

Détails

ID Serval
serval:BIB_D7B474C45266
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Pineal parenchymal tumors of intermediate differentiation in adults: case report and literature review.
Périodique
Neuropathology
Auteur⸱e⸱s
Pusztaszeri M., Pica A., Janzer R.
ISSN
0919-6544
Statut éditorial
Publié
Date de publication
04/2006
Peer-reviewed
Oui
Volume
26
Numéro
2
Pages
153-157
Langue
anglais
Notes
Case Reports Journal Article --- Old month value: Apr
Résumé
Pineal parenchymal tumors (PPT), including pineoblastomas, are very uncommon, especially in adults. Because of the small number of reported cases, the histological and biological features of these tumors are still being defined, as is their optimal management. Also, the pathological variability of these tumors makes it difficult to draw general conclusions about their behavior. We report the case of a PPT of intermediate differentiation (PPTID) with an excellent outcome. A 3.2 cm tumor in the pineal and tectal region with obstructive hydrocephalus was found in a 28-year-old female complaining of headaches and hypoesthesia of the right side of the face. Stereotactic biopsy revealed a highly cellular tumor composed of small cells that contained little cytoplasm that were arranged in a diffuse pattern. Mitotic activity was low and there was no evidence of necrosis. Immunohistochemical examination demonstrated positive staining for neuron-specific enolase and synaptophysin. There was no expression of neurofilaments or GFAP. Ki-67 proliferation index was 12%. The diagnosis was a PPTID. Treatment consisted of combined neoadjuvant chemotherapy and craniospinal radiotherapy. Six years after treatment, the patient is alive and free of any clinical or radiological signs of relapse. This paper discusses the pathological and biological features of these tumors and the treatment options available.
Mots-clé
Adult, Antineoplastic Agents, Brain Neoplasms, Cell Differentiation, Female, Humans, Immunohistochemistry, Neoadjuvant Therapy, Pineal Gland, Pinealoma, Radiotherapy
Pubmed
Web of science
Création de la notice
24/01/2008 17:18
Dernière modification de la notice
20/08/2019 15:57
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