Pineal parenchymal tumors of intermediate differentiation in adults: case report and literature review.

Details

Serval ID
serval:BIB_D7B474C45266
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Pineal parenchymal tumors of intermediate differentiation in adults: case report and literature review.
Journal
Neuropathology
Author(s)
Pusztaszeri M., Pica A., Janzer R.
ISSN
0919-6544
Publication state
Published
Issued date
04/2006
Peer-reviewed
Oui
Volume
26
Number
2
Pages
153-157
Language
english
Notes
Case Reports Journal Article --- Old month value: Apr
Abstract
Pineal parenchymal tumors (PPT), including pineoblastomas, are very uncommon, especially in adults. Because of the small number of reported cases, the histological and biological features of these tumors are still being defined, as is their optimal management. Also, the pathological variability of these tumors makes it difficult to draw general conclusions about their behavior. We report the case of a PPT of intermediate differentiation (PPTID) with an excellent outcome. A 3.2 cm tumor in the pineal and tectal region with obstructive hydrocephalus was found in a 28-year-old female complaining of headaches and hypoesthesia of the right side of the face. Stereotactic biopsy revealed a highly cellular tumor composed of small cells that contained little cytoplasm that were arranged in a diffuse pattern. Mitotic activity was low and there was no evidence of necrosis. Immunohistochemical examination demonstrated positive staining for neuron-specific enolase and synaptophysin. There was no expression of neurofilaments or GFAP. Ki-67 proliferation index was 12%. The diagnosis was a PPTID. Treatment consisted of combined neoadjuvant chemotherapy and craniospinal radiotherapy. Six years after treatment, the patient is alive and free of any clinical or radiological signs of relapse. This paper discusses the pathological and biological features of these tumors and the treatment options available.
Keywords
Adult, Antineoplastic Agents, Brain Neoplasms, Cell Differentiation, Female, Humans, Immunohistochemistry, Neoadjuvant Therapy, Pineal Gland, Pinealoma, Radiotherapy
Pubmed
Web of science
Create date
24/01/2008 17:18
Last modification date
20/08/2019 15:57
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