Physiological ligands of PPARs in inflammation and lipid homeostasis

Détails

ID Serval
serval:BIB_D78B39FC9AC1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Physiological ligands of PPARs in inflammation and lipid homeostasis
Périodique
Future Lipidology
Auteur⸱e⸱s
Lathion C., Michalik L., Wahli W.
ISSN
1746-0875
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
1
Numéro
2
Pages
191-201
Langue
anglais
Résumé
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that are involved in many physiological processes, such as inflammation and energy homeostasis. In general, PPARs must be activated by ligands to stimulate the expression of their target genes. These agonists can be synthetic molecules, such as drugs used to treat hypertriglyceridemia and insulin resistance, or natural physiological ligands, such as fatty acids and eicosanoids. Although recent work has uncovered a surprisingly broad variety of natural molecules capable of activating PPARs, relatively little is known about their mode of action in an in vivo physiological context. The action of physiological ligands in situations of food deprivation and abundance, especially with respect to their intervention in the inflammatory response, and in both lipid homeostasis and inflammation resolution will be reviewed.
Web of science
Création de la notice
28/05/2009 13:14
Dernière modification de la notice
20/08/2019 15:57
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