Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes.

Détails

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ID Serval
serval:BIB_D6E6CF6AE4C5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes.
Périodique
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Auteur(s)
Jonassaint C.R., Szatkiewicz J.P., Bulik C.M., Thornton L.M., Bloss C., Berrettini W.H., Kaye W.H., Bergen A.W., Magistretti P., Strober M., Keel P.K., Brandt H., Crawford S., Crow S., Fichter M.M., Goldman D., Halmi K.A., Johnson C., Kaplan A.S., Klump K.L., La Via M., Mitchell J.E., Rotondo A., Treasure J., Woodside D.B.
ISSN
1552-485X (Electronic)
ISSN-L
1552-4841
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
156
Numéro
4
Pages
454-461
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single-nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1,085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls. © 2011 Wiley-Liss, Inc.
Pubmed
Web of science
Création de la notice
03/05/2011 13:20
Dernière modification de la notice
20/08/2019 15:56
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