Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: Final published version
Secondary document(s)
Download: 21438147_Postprint.pdf (544.98 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_D6E6CF6AE4C5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes.
Journal
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Author(s)
Jonassaint C.R., Szatkiewicz J.P., Bulik C.M., Thornton L.M., Bloss C., Berrettini W.H., Kaye W.H., Bergen A.W., Magistretti P., Strober M., Keel P.K., Brandt H., Crawford S., Crow S., Fichter M.M., Goldman D., Halmi K.A., Johnson C., Kaplan A.S., Klump K.L., La Via M., Mitchell J.E., Rotondo A., Treasure J., Woodside D.B.
ISSN
1552-485X (Electronic)
ISSN-L
1552-4841
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
156
Number
4
Pages
454-461
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single-nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1,085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls. © 2011 Wiley-Liss, Inc.
Pubmed
Web of science
Create date
03/05/2011 13:20
Last modification date
20/08/2019 15:56
Usage data