Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adrenal chromaffin cells through the AT1 receptor.

Détails

ID Serval
serval:BIB_D666383BD07A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adrenal chromaffin cells through the AT1 receptor.
Périodique
Regulatory Peptides
Auteur(s)
Cavadas C., Grand D., Mosimann F., Cotrim M.D., Fontes Ribeiro C.A., Brunner H.R., Grouzmann E.
ISSN
0167-0115
Statut éditorial
Publié
Date de publication
03/2003
Peer-reviewed
Oui
Volume
111
Numéro
1-3
Pages
61-65
Langue
anglais
Notes
Publication types: Journal Article. - Old month value: Mar 28
Résumé
The aim of the present work was to study the effect of angiotensin II (Ang II) on catecholamines and neuropeptide Y (NPY) release in primary cultures of human adrenal chromaffin cells. Ang II stimulates norepinephrine (NE), epinephrine (EP) and NPY release from perifused chromaffin cells by 3-, 2- and 12-fold, respectively. The NPY release is more sustained than that of catecholamines. We found that the receptor-AT(2) agonist, T(2)-(Ang II 4-8)(2) has no effect on NE, EP and NPY release from chromaffin cells. We further showed that Ang II increases intracellular Ca(2+) concentration ([Ca(2+)](i)). The selective AT(1)-receptor antagonist Candesartan blocked [Ca(2+)](i) increase by Ang II, while T(2)-(Ang II 4-8)(2) was ineffective. These findings demonstrate that AT(1) stimulation induces catecholamine secretion from human adrenal chromaffin cells probably by raising cytosolic calcium.
Mots-clé
Adrenal Glands/cytology, Angiotensin II/metabolism, Angiotensin II/pharmacology, Angiotensin II Type 1 Receptor Blockers, Calcium/chemistry, Calcium/metabolism, Cells, Cultured, Chromaffin Cells/drug effects, Chromaffin Cells/metabolism, Epinephrine/secretion, Humans, Neuropeptide Y/secretion, Norepinephrine/secretion, Receptor, Angiotensin, Type 1/agonists, Receptor, Angiotensin, Type 1/metabolism, Signal Transduction
Pubmed
Web of science
Création de la notice
25/01/2008 11:55
Dernière modification de la notice
20/08/2019 16:56
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