Encoded self-assembling chemical libraries

Détails

ID Serval
serval:BIB_D550DBAE9072
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Encoded self-assembling chemical libraries
Périodique
CHIMIA
Auteur(s)
Melkko S., Sobek J., Guarda G., Scheuermann J., Dumelin C.E., Neri D.
ISSN
0009-4293
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
59
Numéro
11
Pages
798-802
Langue
anglais
Résumé
The display of chemical moieties at the extremity of synthetic oligonucleotides allows the self-assembly of large chemical libraries in which every chemical moiety is associated to a unique DNA sequence, serving as an 'identification bar code'. In this article, we describe the principles, the potential, and the challenges of this novel technology, which promises to facilitate the isolation of high-affinity binders to protein targets of biological and pharmaceutical interest.
Mots-clé
affinity maturation, combinatorial chemistry, DNA-templated chemistry, encoded self-assembling chemical libraries, lead identification
Web of science
Création de la notice
13/03/2012 16:47
Dernière modification de la notice
20/08/2019 16:55
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