Encoded self-assembling chemical libraries

Details

Serval ID
serval:BIB_D550DBAE9072
Type
Article: article from journal or magazin.
Collection
Publications
Title
Encoded self-assembling chemical libraries
Journal
CHIMIA
Author(s)
Melkko S., Sobek J., Guarda G., Scheuermann J., Dumelin C.E., Neri D.
ISSN
0009-4293
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
59
Number
11
Pages
798-802
Language
english
Abstract
The display of chemical moieties at the extremity of synthetic oligonucleotides allows the self-assembly of large chemical libraries in which every chemical moiety is associated to a unique DNA sequence, serving as an 'identification bar code'. In this article, we describe the principles, the potential, and the challenges of this novel technology, which promises to facilitate the isolation of high-affinity binders to protein targets of biological and pharmaceutical interest.
Keywords
affinity maturation, combinatorial chemistry, DNA-templated chemistry, encoded self-assembling chemical libraries, lead identification
Web of science
Create date
13/03/2012 15:47
Last modification date
20/08/2019 15:55
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