Double-blind comparison of indapamide with a placebo in hypertensive patients treated by practicing physicians.

Détails

ID Serval
serval:BIB_D513107574CD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Double-blind comparison of indapamide with a placebo in hypertensive patients treated by practicing physicians.
Périodique
Clinical and Experimental Hypertension. Part A, Theory and Practice
Auteur(s)
Schaller M.D., Waeber B., Brunner H.R.
ISSN
1064-1963
0730-0077 (Print)
ISSN-L
0730-0077
Statut éditorial
Publié
Date de publication
1985
Volume
7
Numéro
7
Pages
985-994
Langue
anglais
Notes
Publication types: Clinical Trial ; Comparative Study ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
The antihypertensive effect of indapamide (2.5 mg/day) was compared to that obtained with a placebo in a controlled trial carried out by 11 physicians in their private practice. Thirty-one patients with uncomplicated essential hypertension were included. After a run-in period of 3 weeks without any treatment, either indapamide (n = 16) or a placebo (n = 15) were administered for 8 weeks in double-blind fashion. Blood pressure decreased in both groups. In patients treated with indapamide, systolic pressure was significantly lower than in those given the placebo at 3 out of the 4 follow-up visits; diastolic pressure, however, was significantly lower only at the end of the trial. Both the active drug and the placebo were well tolerated. No significant change in body weight, plasma potassium and uric acid occurred during the study in either group of patients. It appears therefore that indapamide, at a dose which apparently has no major diuretic effect, may be useful for practitioners in managing patients with mild to moderate hypertension.
Mots-clé
Adult, Aged, Blood Pressure/drug effects, Clinical Trials as Topic, Diuretics/therapeutic use, Double-Blind Method, Female, Humans, Hypertension/drug therapy, Indapamide/therapeutic use, Male, Middle Aged
Pubmed
Web of science
Création de la notice
08/09/2011 20:17
Dernière modification de la notice
20/08/2019 15:54
Données d'usage