Article: article from journal or magazin.
Double-blind comparison of indapamide with a placebo in hypertensive patients treated by practicing physicians.
Clinical and Experimental Hypertension. Part A, Theory and Practice
Publication types: Clinical Trial ; Comparative Study ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
The antihypertensive effect of indapamide (2.5 mg/day) was compared to that obtained with a placebo in a controlled trial carried out by 11 physicians in their private practice. Thirty-one patients with uncomplicated essential hypertension were included. After a run-in period of 3 weeks without any treatment, either indapamide (n = 16) or a placebo (n = 15) were administered for 8 weeks in double-blind fashion. Blood pressure decreased in both groups. In patients treated with indapamide, systolic pressure was significantly lower than in those given the placebo at 3 out of the 4 follow-up visits; diastolic pressure, however, was significantly lower only at the end of the trial. Both the active drug and the placebo were well tolerated. No significant change in body weight, plasma potassium and uric acid occurred during the study in either group of patients. It appears therefore that indapamide, at a dose which apparently has no major diuretic effect, may be useful for practitioners in managing patients with mild to moderate hypertension.
Adult, Aged, Blood Pressure/drug effects, Clinical Trials as Topic, Diuretics/therapeutic use, Double-Blind Method, Female, Humans, Hypertension/drug therapy, Indapamide/therapeutic use, Male, Middle Aged
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