Comparison of different immunoassays and GC-MS screening of benzodiazepines in urine.

Détails

ID Serval
serval:BIB_D4FA90596B20
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Comparison of different immunoassays and GC-MS screening of benzodiazepines in urine.
Périodique
Journal of Pharmaceutical and Biomedical Analysis
Auteur(s)
Augsburger M., Rivier L., Mangin P.
ISSN
0731-7085
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
18
Numéro
4-5
Pages
681-687
Langue
anglais
Résumé
A total of 53 urine samples were tested by different immunoassay methods and by gas chromatography/mass spectrometry to determine repeatability of the different methods and to assess whether the immunoassays performed on samples obtained from elderly patients of the emergency section could be considered as reliable enough for identifying a benzodiazepine consumption. Repeatability was excellent for GC/MS and good for immunoassays. The specificity was not different for the three immunoassays (96%). The sensitivity varied from 36, 64 to 75% for OnLine, RIA Immunalysis and RIA DPC, respectively. An other difference between immunoassays and GC/MS was the ability of GC/MS to detect lorazepam and low concentrations of benzodiazepines whereas immunoassays did not.
Mots-clé
Anti-Anxiety Agents, Benzodiazepines, Gas Chromatography-Mass Spectrometry, Humans, Immunoassay, Lorazepam, Reproducibility of Results, Sensitivity and Specificity
Pubmed
Web of science
Création de la notice
08/02/2008 18:43
Dernière modification de la notice
20/08/2019 16:54
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