Comparison of different immunoassays and GC-MS screening of benzodiazepines in urine.

Details

Serval ID
serval:BIB_D4FA90596B20
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of different immunoassays and GC-MS screening of benzodiazepines in urine.
Journal
Journal of Pharmaceutical and Biomedical Analysis
Author(s)
Augsburger M., Rivier L., Mangin P.
ISSN
0731-7085
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
18
Number
4-5
Pages
681-687
Language
english
Abstract
A total of 53 urine samples were tested by different immunoassay methods and by gas chromatography/mass spectrometry to determine repeatability of the different methods and to assess whether the immunoassays performed on samples obtained from elderly patients of the emergency section could be considered as reliable enough for identifying a benzodiazepine consumption. Repeatability was excellent for GC/MS and good for immunoassays. The specificity was not different for the three immunoassays (96%). The sensitivity varied from 36, 64 to 75% for OnLine, RIA Immunalysis and RIA DPC, respectively. An other difference between immunoassays and GC/MS was the ability of GC/MS to detect lorazepam and low concentrations of benzodiazepines whereas immunoassays did not.
Keywords
Anti-Anxiety Agents, Benzodiazepines, Gas Chromatography-Mass Spectrometry, Humans, Immunoassay, Lorazepam, Reproducibility of Results, Sensitivity and Specificity
Pubmed
Web of science
Create date
08/02/2008 17:43
Last modification date
20/08/2019 15:54
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