Molecular bases of circadian rhythmicity in renal physiology and pathology.

Détails

Ressource 1Télécharger: serval:BIB_D4E58F4B31B0.P001 (286.90 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_D4E58F4B31B0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Molecular bases of circadian rhythmicity in renal physiology and pathology.
Périodique
Nephrology, Dialysis, Transplantation
Auteur(s)
Bonny O., Vinciguerra M., Gumz M.L., Mazzoccoli G.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Statut éditorial
Publié
Date de publication
2013
Volume
28
Numéro
10
Pages
2421-2431
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish Document Type: Review
Résumé
The physiological processes that maintain body homeostasis oscillate during the day. Diurnal changes characterize kidney functions, comprising regulation of hydro-electrolytic and acid-base balance, reabsorption of small solutes and hormone production. Renal physiology is characterized by 24-h periodicity and contributes to circadian variability of blood pressure levels, related as well to nychthemeral changes of sodium sensitivity, physical activity, vascular tone, autonomic function and neurotransmitter release from sympathetic innervations. The circadian rhythmicity of body physiology is driven by central and peripheral biological clockworks and entrained by the geophysical light/dark cycle. Chronodisruption, defined as the mismatch between environmental-social cues and physiological-behavioral patterns, causes internal desynchronization of periodic functions, leading to pathophysiological mechanisms underlying degenerative, immune related, metabolic and neoplastic diseases. In this review we will address the genetic, molecular and anatomical elements that hardwire circadian rhythmicity in renal physiology and subtend disarray of time-dependent changes in renal pathology.
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/10/2013 17:51
Dernière modification de la notice
20/10/2020 11:08
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