Molecular bases of circadian rhythmicity in renal physiology and pathology.

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Serval ID
serval:BIB_D4E58F4B31B0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Molecular bases of circadian rhythmicity in renal physiology and pathology.
Journal
Nephrology, Dialysis, Transplantation
Author(s)
Bonny O., Vinciguerra M., Gumz M.L., Mazzoccoli G.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Publication state
Published
Issued date
2013
Volume
28
Number
10
Pages
2421-2431
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish Document Type: Review
Abstract
The physiological processes that maintain body homeostasis oscillate during the day. Diurnal changes characterize kidney functions, comprising regulation of hydro-electrolytic and acid-base balance, reabsorption of small solutes and hormone production. Renal physiology is characterized by 24-h periodicity and contributes to circadian variability of blood pressure levels, related as well to nychthemeral changes of sodium sensitivity, physical activity, vascular tone, autonomic function and neurotransmitter release from sympathetic innervations. The circadian rhythmicity of body physiology is driven by central and peripheral biological clockworks and entrained by the geophysical light/dark cycle. Chronodisruption, defined as the mismatch between environmental-social cues and physiological-behavioral patterns, causes internal desynchronization of periodic functions, leading to pathophysiological mechanisms underlying degenerative, immune related, metabolic and neoplastic diseases. In this review we will address the genetic, molecular and anatomical elements that hardwire circadian rhythmicity in renal physiology and subtend disarray of time-dependent changes in renal pathology.
Pubmed
Web of science
Open Access
Yes
Create date
24/10/2013 17:51
Last modification date
25/09/2019 7:10
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