Blood pressure and heart rate effect of a vasopressin antagonist in conscious normotensive rats pretreated with exogenous vasopressin

Détails

ID Serval
serval:BIB_D2121522F4DD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Blood pressure and heart rate effect of a vasopressin antagonist in conscious normotensive rats pretreated with exogenous vasopressin
Périodique
European Journal of Pharmacology
Auteur⸱e⸱s
Waeber  B., Nussberger  J., Brunner  H. R.
ISSN
0014-2999 (Print)
Statut éditorial
Publié
Date de publication
07/1983
Volume
91
Numéro
1
Pages
135-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 15
Résumé
The blood pressure and heart rate effects of the specific pressor antagonist of vasopressin d(CH2)5Tyr(Me)AVP, 5 micrograms i.v. was evaluated in conscious normotensive rats. Our results suggest that a baroreceptor reflex mediated decrease in sympathetic nerve activity, as reflected by a slowing in heart rate, returns blood pressure to baseline levels shortly after injections of exogenous vasopressin. This has to be taken into account when interpreting the hemodynamic response to vasopressin antagonists in rats pretreated with this vasopressive hormone.
Mots-clé
Animals Arginine Vasopressin/*analogs & derivatives/pharmacology Blood Pressure/*drug effects Dose-Response Relationship, Drug Heart Rate/*drug effects Lysine Vasopressin/pharmacology Male Rats Rats, Inbred Strains Time Factors Vasopressins/*antagonists & inhibitors
Pubmed
Web of science
Création de la notice
05/03/2008 16:39
Dernière modification de la notice
20/08/2019 15:52
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