Blood pressure and heart rate effect of a vasopressin antagonist in conscious normotensive rats pretreated with exogenous vasopressin
Details
Serval ID
serval:BIB_D2121522F4DD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Blood pressure and heart rate effect of a vasopressin antagonist in conscious normotensive rats pretreated with exogenous vasopressin
Journal
European Journal of Pharmacology
ISSN
0014-2999 (Print)
Publication state
Published
Issued date
07/1983
Volume
91
Number
1
Pages
135-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 15
Research Support, Non-U.S. Gov't --- Old month value: Jul 15
Abstract
The blood pressure and heart rate effects of the specific pressor antagonist of vasopressin d(CH2)5Tyr(Me)AVP, 5 micrograms i.v. was evaluated in conscious normotensive rats. Our results suggest that a baroreceptor reflex mediated decrease in sympathetic nerve activity, as reflected by a slowing in heart rate, returns blood pressure to baseline levels shortly after injections of exogenous vasopressin. This has to be taken into account when interpreting the hemodynamic response to vasopressin antagonists in rats pretreated with this vasopressive hormone.
Keywords
Animals
Arginine Vasopressin/*analogs & derivatives/pharmacology
Blood Pressure/*drug effects
Dose-Response Relationship, Drug
Heart Rate/*drug effects
Lysine Vasopressin/pharmacology
Male
Rats
Rats, Inbred Strains
Time Factors
Vasopressins/*antagonists & inhibitors
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 15:52
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