Analysis of virologic and immunologic events in HIV infection

Détails

ID Serval
serval:BIB_D1F900588800
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Compte-rendu: analyse d'une oeuvre publiée.
Collection
Publications
Institution
Titre
Analysis of virologic and immunologic events in HIV infection
Périodique
Pathobiology
Auteur(s)
Graziosi  C., Pantaleo  G.
ISSN
1015-2008 (Print)
Statut éditorial
Publié
Date de publication
1998
Volume
66
Numéro
3-4
Pages
123-7
Notes
Lectures
Résumé
A number of pathogenic events occurring immediately after the transmission of HIV lead to the establishment of chronic infection. In fact, despite the detection of vigorous virus-specific immune responses during primary infection, HIV is able to establish chronic infection in most of the cases. This is the result of several virologic and immunologic mechanisms that HIV has evolved to escape and/or to weaken virus-specific immune responses. Lymphoid organs represent the primary anatomic site for the establishment of chronic infection, and if highly active antiretroviral therapy is not initiated in early stage disease, there is a progressive destruction of lymphoid tissue that ultimately leads to the profound immunosuppression typical of AIDS. Therefore, analysis of lymphoid organs is crucial for the correct evaluation of the effectiveness of antiretroviral therapy in HIV infection.
Mots-clé
Acute Disease Chronic Disease HIV Infections/*immunology/therapy/*virology Humans Immune Tolerance Immunity, Cellular
Pubmed
Web of science
Création de la notice
25/01/2008 14:58
Dernière modification de la notice
20/08/2019 15:52
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