Analysis of virologic and immunologic events in HIV infection

Details

Serval ID
serval:BIB_D1F900588800
Type
Article: article from journal or magazin.
Publication sub-type
Minutes: analyse of a published work.
Collection
Publications
Institution
Title
Analysis of virologic and immunologic events in HIV infection
Journal
Pathobiology
Author(s)
Graziosi  C., Pantaleo  G.
ISSN
1015-2008 (Print)
Publication state
Published
Issued date
1998
Volume
66
Number
3-4
Pages
123-7
Notes
Lectures
Abstract
A number of pathogenic events occurring immediately after the transmission of HIV lead to the establishment of chronic infection. In fact, despite the detection of vigorous virus-specific immune responses during primary infection, HIV is able to establish chronic infection in most of the cases. This is the result of several virologic and immunologic mechanisms that HIV has evolved to escape and/or to weaken virus-specific immune responses. Lymphoid organs represent the primary anatomic site for the establishment of chronic infection, and if highly active antiretroviral therapy is not initiated in early stage disease, there is a progressive destruction of lymphoid tissue that ultimately leads to the profound immunosuppression typical of AIDS. Therefore, analysis of lymphoid organs is crucial for the correct evaluation of the effectiveness of antiretroviral therapy in HIV infection.
Keywords
Acute Disease Chronic Disease HIV Infections/*immunology/therapy/*virology Humans Immune Tolerance Immunity, Cellular
Pubmed
Web of science
Create date
25/01/2008 14:58
Last modification date
20/08/2019 15:52
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