Death following acute poisoning by moclobemide

Détails

ID Serval
serval:BIB_D1D5C6BC8350
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Death following acute poisoning by moclobemide
Périodique
Forensic science international
Auteur(s)
Giroud C., Horisberger B., Eap C., Augsburger M., Ménétrey A., Baumann P., Mangin P.
ISSN
0379-0738
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
140
Numéro
1
Pages
101-107
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Résumé
A fatality due to ingestion of a reversible inhibitor of monoamine-oxidase A (MAO-A) is reported. Moclobemide is generally considered as a safe drug far less toxic than tricyclic anti-depressants. However, severe intoxications may result from interactions with other drugs and food such as selective serotonin reuptake inhibitors (SSRIs), anti-Parkinsonians of the MAOI-type (e.g. selegiline) or tyramine from ripe cheese or other sources. In the present case, high levels of moclobemide were measured in peripheral blood exceeding toxic values reported so far in the scientific literature. The body fluid concentrations of moclobemide were of 498 mg/l in peripheral whole blood, 96.3 mg/l in urine while an amount of approximately 33 g could be recovered from gastric contents. The other xenobiotics were considered of little toxicological relevance. The victim (male, 48-year-old) had a past history of depression and committed one suicide attempt 2 years before death. Autopsy revealed no evidence of significant natural disease or injury. It was concluded that the manner of death was suicide and that the unique cause of death was massive ingestion of moclobemide.
Mots-clé
Antidepressive Agents, Benzodiazepines, Central Nervous System Depressants, Ethanol, Humans, Male, Middle Aged, Moclobemide, Molecular Structure, Overdose
Pubmed
Web of science
Création de la notice
02/03/2008 22:35
Dernière modification de la notice
20/08/2019 15:51
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