Developmental dynamics of lncRNAs across mammalian organs and species.
Détails
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_D1A9C3A8AA0F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Developmental dynamics of lncRNAs across mammalian organs and species.
Périodique
Nature
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
07/2019
Peer-reviewed
Oui
Volume
571
Numéro
7766
Pages
510-514
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Although many long noncoding RNAs (lncRNAs) have been identified in human and other mammalian genomes, there has been limited systematic functional characterization of these elements. In particular, the contribution of lncRNAs to organ development remains largely unexplored. Here we analyse the expression patterns of lncRNAs across developmental time points in seven major organs, from early organogenesis to adulthood, in seven species (human, rhesus macaque, mouse, rat, rabbit, opossum and chicken). Our analyses identified approximately 15,000 to 35,000 candidate lncRNAs in each species, most of which show species specificity. We characterized the expression patterns of lncRNAs across developmental stages, and found many with dynamic expression patterns across time that show signatures of enrichment for functionality. During development, there is a transition from broadly expressed and conserved lncRNAs towards an increasing number of lineage- and organ-specific lncRNAs. Our study provides a resource of candidate lncRNAs and their patterns of expression and evolutionary conservation across mammalian organ development.
Mots-clé
Animals, Atlases as Topic, Chickens/genetics, Evolution, Molecular, Female, Gene Expression Regulation, Developmental, Humans, Macaca mulatta/genetics, Male, Mice, Opossums/genetics, Organ Specificity/genetics, Organogenesis/genetics, Proteins/genetics, RNA, Long Noncoding/analysis, RNA, Long Noncoding/genetics, RNA, Long Noncoding/metabolism, Rabbits, Rats, Species Specificity
Pubmed
Web of science
Création de la notice
18/07/2019 18:32
Dernière modification de la notice
30/04/2021 7:15