Developmental dynamics of lncRNAs across mammalian organs and species.

Details

Serval ID
serval:BIB_D1A9C3A8AA0F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Developmental dynamics of lncRNAs across mammalian organs and species.
Journal
Nature
Author(s)
Sarropoulos I., Marin R., Cardoso-Moreira M., Kaessmann H.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
07/2019
Peer-reviewed
Oui
Volume
571
Number
7766
Pages
510-514
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Although many long noncoding RNAs (lncRNAs) have been identified in human and other mammalian genomes, there has been limited systematic functional characterization of these elements. In particular, the contribution of lncRNAs to organ development remains largely unexplored. Here we analyse the expression patterns of lncRNAs across developmental time points in seven major organs, from early organogenesis to adulthood, in seven species (human, rhesus macaque, mouse, rat, rabbit, opossum and chicken). Our analyses identified approximately 15,000 to 35,000 candidate lncRNAs in each species, most of which show species specificity. We characterized the expression patterns of lncRNAs across developmental stages, and found many with dynamic expression patterns across time that show signatures of enrichment for functionality. During development, there is a transition from broadly expressed and conserved lncRNAs towards an increasing number of lineage- and organ-specific lncRNAs. Our study provides a resource of candidate lncRNAs and their patterns of expression and evolutionary conservation across mammalian organ development.
Keywords
Animals, Atlases as Topic, Chickens/genetics, Evolution, Molecular, Female, Gene Expression Regulation, Developmental, Humans, Macaca mulatta/genetics, Male, Mice, Opossums/genetics, Organ Specificity/genetics, Organogenesis/genetics, Proteins/genetics, RNA, Long Noncoding/analysis, RNA, Long Noncoding/genetics, RNA, Long Noncoding/metabolism, Rabbits, Rats, Species Specificity
Pubmed
Web of science
Create date
18/07/2019 18:32
Last modification date
24/09/2019 6:11
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