Clinical determinants of the PR interval duration in Swiss middle-aged adults: The CoLaus/PsyCoLaus study.

Détails

Ressource 1Télécharger: Clinical Cardiology 2020.pdf (1015.55 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_D102AECA320B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinical determinants of the PR interval duration in Swiss middle-aged adults: The CoLaus/PsyCoLaus study.
Périodique
Clinical cardiology
Auteur(s)
Bay M., Vollenweider P., Marques-Vidal P., Bocchi F., Pruvot E., Schläpfer J.
ISSN
1932-8737 (Electronic)
ISSN-L
0160-9289
Statut éditorial
Publié
Date de publication
06/2020
Peer-reviewed
Oui
Volume
43
Numéro
6
Pages
614-621
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Prolonged PR interval (PRi) is associated with adverse outcomes. However, PRi determinants are poorly known. We aimed to identify the clinical determinants of the PRi duration in the general population.
Some clinical data are associated with prolonged PRi.
Cross-sectional study conducted between 2014 and 2017. Electrocardiogram-derived PRi duration was categorized into normal or prolonged (>200 ms). Determinants were identified using stepwise logistic regression, and results were expressed as multivariable-adjusted odds ratio (OR) (95% confidence interval). A further analysis was performed adjusting for antiarrhythmic drugs, P-wave contribution to PRi duration, electrolytes (kalemia, calcemia, and magnesemia), and history of cardiovascular disease.
Overall, 3655 participants with measurable PRi duration were included (55.6% females; mean age 62 ± 10 years), and 330 (9.0%) had prolonged PRi. Stepwise logistic regression identified male sex (OR 1.41 [1.02-1.97]); aging (65-74 years: OR 2.29 [1.61-3.24], and ≥ 75 years: OR 4.21 [2.81-6.31]); increased height (per 5 cm, OR 1.15 [1.06-1.25]); hypertension (OR 1.37 [1.06-1.77]); and hs troponin T (OR 1.67 [1.15-2.43]) as significantly and positively associated, and high resting heart rate (≥70 beats/min, OR 0.43 [0.29-0.62]) as negatively associated with prolonged PRi. After further adjustment, male sex, aging and increased height remained positively, and high resting heart rate negatively associated with prolonged PRi. Hypertension and hs troponin T were no longer associated.
In a sample of the Swiss middle-aged population, male sex, aging and increased height significantly increased the likelihood of a prolonged PRi duration, whereas a high resting heart rate decreased it.
Mots-clé
PR interval, Switzerland, adults, cross-sectional, determinants, electrocardiogram
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/05/2020 15:38
Dernière modification de la notice
02/09/2020 6:22
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