Clinical determinants of the PR interval duration in Swiss middle-aged adults: The CoLaus/PsyCoLaus study.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_D102AECA320B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical determinants of the PR interval duration in Swiss middle-aged adults: The CoLaus/PsyCoLaus study.
Journal
Clinical cardiology
Author(s)
Bay M., Vollenweider P., Marques-Vidal P., Bocchi F., Pruvot E., Schläpfer J.
ISSN
1932-8737 (Electronic)
ISSN-L
0160-9289
Publication state
Published
Issued date
06/2020
Peer-reviewed
Oui
Volume
43
Number
6
Pages
614-621
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Prolonged PR interval (PRi) is associated with adverse outcomes. However, PRi determinants are poorly known. We aimed to identify the clinical determinants of the PRi duration in the general population.
Some clinical data are associated with prolonged PRi.
Cross-sectional study conducted between 2014 and 2017. Electrocardiogram-derived PRi duration was categorized into normal or prolonged (>200 ms). Determinants were identified using stepwise logistic regression, and results were expressed as multivariable-adjusted odds ratio (OR) (95% confidence interval). A further analysis was performed adjusting for antiarrhythmic drugs, P-wave contribution to PRi duration, electrolytes (kalemia, calcemia, and magnesemia), and history of cardiovascular disease.
Overall, 3655 participants with measurable PRi duration were included (55.6% females; mean age 62 ± 10 years), and 330 (9.0%) had prolonged PRi. Stepwise logistic regression identified male sex (OR 1.41 [1.02-1.97]); aging (65-74 years: OR 2.29 [1.61-3.24], and ≥ 75 years: OR 4.21 [2.81-6.31]); increased height (per 5 cm, OR 1.15 [1.06-1.25]); hypertension (OR 1.37 [1.06-1.77]); and hs troponin T (OR 1.67 [1.15-2.43]) as significantly and positively associated, and high resting heart rate (≥70 beats/min, OR 0.43 [0.29-0.62]) as negatively associated with prolonged PRi. After further adjustment, male sex, aging and increased height remained positively, and high resting heart rate negatively associated with prolonged PRi. Hypertension and hs troponin T were no longer associated.
In a sample of the Swiss middle-aged population, male sex, aging and increased height significantly increased the likelihood of a prolonged PRi duration, whereas a high resting heart rate decreased it.
Keywords
PR interval, Switzerland, adults, cross-sectional, determinants, electrocardiogram
Pubmed
Web of science
Open Access
Yes
Create date
02/05/2020 15:38
Last modification date
02/09/2020 6:22
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