Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.

Détails

ID Serval
serval:BIB_CFE4DBFE5531
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur⸱e⸱s
Fleury S., Rizzardi G.P., Chapuis A., Tambussi G., Knabenhans C., Simeoni E., Meuwly J.Y., Corpataux J.M., Lazzarin A., Miedema F., Pantaleo G.
ISSN
0027-8424
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
97
Numéro
10
Pages
5393-5398
Langue
anglais
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
Résumé
The long-term kinetics of T cell production following highly active antiretroviral therapy (HAART) were investigated in blood and lymph node in a group of HIV-infected subjects at early stage of established infection and prospectively studied for 72 wk. Before HAART, CD4 and CD8 T cell turnover was increased. However, the total number of proliferating CD4(+) T lymphocytes, i.e., CD4(+)Ki67(+) T lymphocytes, was not significantly different in HIV-infected (n = 73) and HIV-negative (n = 15) subjects, whereas proliferating CD8(+)Ki67(+) T lymphocytes were significantly higher in HIV-infected subjects. After HAART, the total body number of proliferating CD4(+)Ki67(+) T lymphocytes increased over time and was associated with an increase of both naive and memory CD4(+) T cells. The maximal increase (2-fold) was observed at week 36, whereas at week 72 the number of proliferating CD4(+) T cells dropped to baseline levels, i.e., before HAART. The kinetics of the fraction of proliferating CD4 and CD8 T cells were significantly correlated with the changes in the total body number of these T cell subsets. These results demonstrate a direct relationship between ex vivo measures of T cell production and quantitative changes in total body T lymphocyte populations. This study provides advances in the delineation of the kinetics of T cell production in HIV infection in the presence and/or in the absence of HAART.
Mots-clé
Adult, Anti-HIV Agents, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Dideoxynucleosides, Drug Therapy, Combination, HIV Infections, HIV Seronegativity, Humans, Kinetics, Lymph Nodes, Lymphocyte Activation, Middle Aged, Nelfinavir, Regression Analysis, Saquinavir, T-Lymphocyte Subsets, T-Lymphocytes, Time Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 9:01
Dernière modification de la notice
20/08/2019 15:50
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