Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.

Details

Serval ID
serval:BIB_CFE4DBFE5531
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Fleury S., Rizzardi G.P., Chapuis A., Tambussi G., Knabenhans C., Simeoni E., Meuwly J.Y., Corpataux J.M., Lazzarin A., Miedema F., Pantaleo G.
ISSN
0027-8424
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
97
Number
10
Pages
5393-5398
Language
english
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
Abstract
The long-term kinetics of T cell production following highly active antiretroviral therapy (HAART) were investigated in blood and lymph node in a group of HIV-infected subjects at early stage of established infection and prospectively studied for 72 wk. Before HAART, CD4 and CD8 T cell turnover was increased. However, the total number of proliferating CD4(+) T lymphocytes, i.e., CD4(+)Ki67(+) T lymphocytes, was not significantly different in HIV-infected (n = 73) and HIV-negative (n = 15) subjects, whereas proliferating CD8(+)Ki67(+) T lymphocytes were significantly higher in HIV-infected subjects. After HAART, the total body number of proliferating CD4(+)Ki67(+) T lymphocytes increased over time and was associated with an increase of both naive and memory CD4(+) T cells. The maximal increase (2-fold) was observed at week 36, whereas at week 72 the number of proliferating CD4(+) T cells dropped to baseline levels, i.e., before HAART. The kinetics of the fraction of proliferating CD4 and CD8 T cells were significantly correlated with the changes in the total body number of these T cell subsets. These results demonstrate a direct relationship between ex vivo measures of T cell production and quantitative changes in total body T lymphocyte populations. This study provides advances in the delineation of the kinetics of T cell production in HIV infection in the presence and/or in the absence of HAART.
Keywords
Adult, Anti-HIV Agents, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Dideoxynucleosides, Drug Therapy, Combination, HIV Infections, HIV Seronegativity, Humans, Kinetics, Lymph Nodes, Lymphocyte Activation, Middle Aged, Nelfinavir, Regression Analysis, Saquinavir, T-Lymphocyte Subsets, T-Lymphocytes, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 10:01
Last modification date
20/08/2019 16:50
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