Evaluation of SuperCAZ/AVI® Medium for Screening Ceftazidime-avibactam Resistant Gram-negative Isolates.

Sadek, M.; Poirel, L.; Dominguez Pino, M.; D'Emidio, F.; Pomponio, S.; Nordmann, P.

doi:10.1016/j.diagmicrobio.2021.115475

Evaluation of SuperCAZ/AVI® Medium for Screening Ceftazidime-avibactam Resistant Gram-negative Isolates.

Détails

Télécharger: Evaluation of SuperCAZ-AVI Medium for Screening Ceftazidime-avibactam Resistant Gram-negative Isolates.pdf (307.39 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0

ID Serval

serval:BIB_CFA892B456C6

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Evaluation of SuperCAZ/AVI® Medium for Screening Ceftazidime-avibactam Resistant Gram-negative Isolates.

Périodique

Diagnostic microbiology and infectious disease

Auteur⸱e⸱s

Sadek M., Poirel L., Dominguez Pino M., D'Emidio F., Pomponio S., Nordmann P.

ISSN

1879-0070 (Electronic)

ISSN-L

0732-8893

Statut éditorial

Publié

Date de publication

12/2021

Peer-reviewed

Oui

Volume

101

Numéro

Pages

115475

Langue

anglais

Notes

Publication types: Evaluation Study ; Journal Article
Publication Status: ppublish

Résumé

The industrial version of SuperCAZ/AVI® medium developed for screening CAZ/AVI resistant Gram-negative isolates has been evaluated here using a collection of 87 well-characterized clinical isolates of worldwide origin. In addition, testing was performed by spiking stools with a series of resistant and susceptible isolates. In those conditions, the SuperCAZ/AVI® medium exhibited a sensitivity and specificity of 100 %, down to the lower limit of detection of 10 <sup>1</sup> to 10 <sup>2</sup> CFU/ml. The SuperCAZ/AVI® medium is a sensitive and specific screening medium for detection of CZA-resistant bacteria regardless of their resistance mechanisms.

Mots-clé

Anti-Bacterial Agents/pharmacology, Azabicyclo Compounds/pharmacology, Ceftazidime/pharmacology, Culture Media, Drug Combinations, Drug Resistance, Multiple, Bacterial/drug effects, Feces/microbiology, Gram-Negative Bacteria/drug effects, Gram-Negative Bacteria/isolation & purification, Gram-Negative Bacterial Infections/diagnosis, Gram-Negative Bacterial Infections/microbiology, Humans, Limit of Detection, Microbial Sensitivity Tests/instrumentation, Sensitivity and Specificity, beta-Lactamase Inhibitors/pharmacology

URN

urn:nbn:ch:serval-BIB_CFA892B456C62

OAI-PMH

oai:serval.unil.ch:BIB_CFA892B456C6

DOI

10.1016/j.diagmicrobio.2021.115475

Pubmed

34419742

Web of science

000703607900011

Open Access

Oui