Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection.

Détails

ID Serval
serval:BIB_CF978BE093A6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection.
Périodique
Zeitschrift Für Rechtsmedizin. Journal of Legal Medicine
Auteur⸱e⸱s
Kintz P., Mangin P., Lugnier A.A., Chaumont A.J.
ISSN
0044-3433[print], 0044-3433[linking]
Statut éditorial
Publié
Date de publication
1989
Volume
103
Numéro
1
Pages
57-62
Langue
anglais
Résumé
A capillary column gas chromatographic method is described for the simultaneous determination of morphine, codeine, heroin, 3- and 6-monoacetylmorphine, nalorphine, naloxone, ethylmorphine, and naltrexone. The drugs were extracted from 2 ml plasma, urine, or other biological samples, including tissue under alkaline conditions in chloroform-isopropanol-n-heptane (50:17:33, v/v), with levallorphan as an internal standard. The drugs were extracted into acid and then reextracted into chloroform after the acid had been alkalinized. After derivatization with trifluoroacetic anhydride, an aliquot was injected into a 25m capillary column equipped with a nitrogen phosphorus detector. The lower limits of detectability, extraction recovery, and the within-run and day-to-day precision of results were determined for each drug. Our results indicate that the procedure is suitable for use in overdose screening and therapeutic drug monitoring.
Mots-clé
Chromatography, Gas/methods, Humans, Nalorphine/pharmacokinetics, Nalorphine/therapeutic use, Naloxone/pharmacokinetics, Naloxone/therapeutic use, Naltrexone/pharmacokinetics, Naltrexone/therapeutic use, Narcotics/pharmacokinetics, Opioid-Related Disorders/blood, Opioid-Related Disorders/rehabilitation
Pubmed
Création de la notice
15/10/2010 13:00
Dernière modification de la notice
20/08/2019 15:50
Données d'usage