Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection.

Details

Serval ID
serval:BIB_CF978BE093A6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection.
Journal
Zeitschrift Für Rechtsmedizin. Journal of Legal Medicine
Author(s)
Kintz P., Mangin P., Lugnier A.A., Chaumont A.J.
ISSN
0044-3433[print], 0044-3433[linking]
Publication state
Published
Issued date
1989
Volume
103
Number
1
Pages
57-62
Language
english
Abstract
A capillary column gas chromatographic method is described for the simultaneous determination of morphine, codeine, heroin, 3- and 6-monoacetylmorphine, nalorphine, naloxone, ethylmorphine, and naltrexone. The drugs were extracted from 2 ml plasma, urine, or other biological samples, including tissue under alkaline conditions in chloroform-isopropanol-n-heptane (50:17:33, v/v), with levallorphan as an internal standard. The drugs were extracted into acid and then reextracted into chloroform after the acid had been alkalinized. After derivatization with trifluoroacetic anhydride, an aliquot was injected into a 25m capillary column equipped with a nitrogen phosphorus detector. The lower limits of detectability, extraction recovery, and the within-run and day-to-day precision of results were determined for each drug. Our results indicate that the procedure is suitable for use in overdose screening and therapeutic drug monitoring.
Keywords
Chromatography, Gas/methods, Humans, Nalorphine/pharmacokinetics, Nalorphine/therapeutic use, Naloxone/pharmacokinetics, Naloxone/therapeutic use, Naltrexone/pharmacokinetics, Naltrexone/therapeutic use, Narcotics/pharmacokinetics, Opioid-Related Disorders/blood, Opioid-Related Disorders/rehabilitation
Pubmed
Create date
15/10/2010 13:00
Last modification date
20/08/2019 15:50
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