Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe.

Détails

ID Serval
serval:BIB_CDF644AF61D8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe.
Périodique
Antimicrobial agents and chemotherapy
Auteur(s)
Poirel L., Aires-de-Sousa M., Kudyba P., Kieffer N., Nordmann P.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Statut éditorial
Publié
Date de publication
09/2018
Peer-reviewed
Oui
Volume
62
Numéro
9
Pages
e01021-1
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The occurrence of resistance to last-resort antibiotics was evaluated among <i>Enterobacteriaceae</i> isolates recovered from hospitalized children in a remote African archipelago, São Tomé and Príncipe, where there is limited access to those antibiotics. Fifty patients were screened for colonization by carbapenem-, pan-aminoglycoside-, or polymyxin-resistant <i>Enterobacteriaceae</i> A total of 36 isolates (including 30 <i>Escherichia coli</i> and 4 <i>Klebsiella pneumoniae</i> ) were recovered from 23 patients, including 26 isolates harboring the <i>bla</i> <sub>OXA-181</sub> carbapenemase gene, a single isolate harboring the 16S rRNA methylase gene <i>rmtB</i> encoding pan-resistance to aminoglycosides, and 8 isolates coharboring both genes. A single isolate possessed the plasmid-borne colistin resistance gene <i>mcr-1</i> A high clonal relationship was found for OXA-181-producing <i>E. coli</i> (4 clones), and conversely, three of the four OXA-181-producing <i>K. pneumoniae</i> isolates were clonally unrelated. This study overall showed a high prevalence of resistance to last-resort antibiotics in this country, where no epidemiological data were previously available.
Mots-clé
MCR, São Tomé and Príncipe, aminoglycosides, carbapenem, carbapenemase, colistin
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/06/2018 17:27
Dernière modification de la notice
20/08/2019 16:48
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