Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe.

Details

Serval ID
serval:BIB_CDF644AF61D8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Poirel L., Aires-de-Sousa M., Kudyba P., Kieffer N., Nordmann P.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
09/2018
Peer-reviewed
Oui
Volume
62
Number
9
Pages
e01021-1
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The occurrence of resistance to last-resort antibiotics was evaluated among <i>Enterobacteriaceae</i> isolates recovered from hospitalized children in a remote African archipelago, São Tomé and Príncipe, where there is limited access to those antibiotics. Fifty patients were screened for colonization by carbapenem-, pan-aminoglycoside-, or polymyxin-resistant <i>Enterobacteriaceae</i> A total of 36 isolates (including 30 <i>Escherichia coli</i> and 4 <i>Klebsiella pneumoniae</i> ) were recovered from 23 patients, including 26 isolates harboring the <i>bla</i> <sub>OXA-181</sub> carbapenemase gene, a single isolate harboring the 16S rRNA methylase gene <i>rmtB</i> encoding pan-resistance to aminoglycosides, and 8 isolates coharboring both genes. A single isolate possessed the plasmid-borne colistin resistance gene <i>mcr-1</i> A high clonal relationship was found for OXA-181-producing <i>E. coli</i> (4 clones), and conversely, three of the four OXA-181-producing <i>K. pneumoniae</i> isolates were clonally unrelated. This study overall showed a high prevalence of resistance to last-resort antibiotics in this country, where no epidemiological data were previously available.
Keywords
MCR, São Tomé and Príncipe, aminoglycosides, carbapenem, carbapenemase, colistin
Pubmed
Web of science
Open Access
Yes
Create date
29/06/2018 17:27
Last modification date
20/08/2019 16:48
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