Les agonistes α2-adrénergiques pour l’intensiviste [Alpha-2 adrenoreceptor agonists for the intensive care physician]
Détails
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Accès restreint UNIL
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_CDD4BF43C3E1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Les agonistes α2-adrénergiques pour l’intensiviste [Alpha-2 adrenoreceptor agonists for the intensive care physician]
Périodique
Revue medicale suisse
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
03/05/2023
Peer-reviewed
Oui
Volume
19
Numéro
825
Pages
872-877
Langue
français
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Clonidine and dexmedetomidine are two α2-adrenoreceptors agonists available for the intensivist in the clinical practice. The affinity of dexmedetomidine is eight times greater than clonidine affinity for the α2 receptors. Their main effect is sedation. They act by inhibition of noradrenaline release in the locus coeruleus in the brainstem. α2-agonists are used primarily for sedation, analgesia, and management of delirium. Nowadays, dexmedetomidine application is increasing in critically ill patients showing a good safety. Most frequent side effects include bradycardia and hypotension.
Mots-clé
Humans, Dexmedetomidine/adverse effects, Clonidine/adverse effects, Adrenergic alpha-2 Receptor Agonists/adverse effects, Hypnotics and Sedatives, Critical Care
Pubmed
Création de la notice
04/05/2023 9:27
Dernière modification de la notice
25/07/2023 7:16