Les agonistes α2-adrénergiques pour l’intensiviste [Alpha-2 adrenoreceptor agonists for the intensive care physician]
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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_CDD4BF43C3E1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Les agonistes α2-adrénergiques pour l’intensiviste [Alpha-2 adrenoreceptor agonists for the intensive care physician]
Journal
Revue medicale suisse
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
03/05/2023
Peer-reviewed
Oui
Volume
19
Number
825
Pages
872-877
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Clonidine and dexmedetomidine are two α2-adrenoreceptors agonists available for the intensivist in the clinical practice. The affinity of dexmedetomidine is eight times greater than clonidine affinity for the α2 receptors. Their main effect is sedation. They act by inhibition of noradrenaline release in the locus coeruleus in the brainstem. α2-agonists are used primarily for sedation, analgesia, and management of delirium. Nowadays, dexmedetomidine application is increasing in critically ill patients showing a good safety. Most frequent side effects include bradycardia and hypotension.
Keywords
Humans, Dexmedetomidine/adverse effects, Clonidine/adverse effects, Adrenergic alpha-2 Receptor Agonists/adverse effects, Hypnotics and Sedatives, Critical Care
Pubmed
Create date
04/05/2023 9:27
Last modification date
25/07/2023 7:16