A systematic review and meta-analysis of HCV clearance.

Détails

ID Serval
serval:BIB_CC51EE2DCFF5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
A systematic review and meta-analysis of HCV clearance.
Périodique
Liver international
Auteur(s)
Gauthiez E., Habfast-Robertson I., Rüeger S., Kutalik Z., Aubert V., Berg T., Cerny A., Gorgievski M., George J., Heim M.H., Malinverni R., Moradpour D., Müllhaupt B., Negro F., Semela D., Semmo N., Villard J., Bibert S., Bochud P.Y.
Collaborateur(s)
Swiss Hepatitis C Cohort Study
ISSN
1478-3231 (Electronic)
ISSN-L
1478-3223
Statut éditorial
Publié
Date de publication
10/2017
Peer-reviewed
Oui
Volume
37
Numéro
10
Pages
1431-1445
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Review
Publication Status: ppublish
Résumé
While hepatitis C exemplifies the role of host genetics in infectious diseases outcomes, there is no comprehensive overview of polymorphisms influencing spontaneous and/or treatment-induced hepatitis C virus clearance. We performed a systematic review and meta-analysis of host polymorphisms associated with these phenotypes. Literature search was conducted using combinations of keywords in three databases. Studies were reviewed and relevant data systematically extracted for subsequent meta-analyses. Polymorphisms from candidate gene studies were tested in two cohorts of HCV-infected patients with available genomic data. The literature search yielded 8'294 citations, among which 262 studies were selected. In the meta-analysis of 27 HLA studies, the most significant associations with spontaneous hepatitis C virus clearance included DQB1*02, DQB1*03, DRB1*04 and DRB1*11. In the meta-analysis of 16 studies of KIR genes and their HLA-ligands, KIR2DS3 was associated with both spontaneous and treatment-induced clearance, and the HLA-C2 ligand with failure to spontaneously clear the virus. In a pooled analysis of 105 candidate genes and two genome-wide association studies, we observed associations of single nucleotide polymorphisms from nine genes (EIF2AK2, IFNAR2, ITPA, MBL2, MX1, OASL, SPP1, TGFB1, TNK2) with response to interferon-based therapy. Meta-analysis of 141 studies confirmed the association of IFNL3/4 polymorphisms with spontaneous and treatment-induced hepatitis C virus clearance, even in previously underpowered groups, such as hepatitis C virus genotypes 2/3-infected patients. This study may contribute to a better understanding of hepatitis C virus immunopathogenesis and highlights the complex role of host genetics in hepatitis C virus clearance.
Mots-clé
Antiviral Agents/therapeutic use, Genotype, HLA Antigens/genetics, Hepacivirus/drug effects, Hepacivirus/genetics, Hepacivirus/pathogenicity, Hepatitis C/diagnosis, Hepatitis C/drug therapy, Hepatitis C/genetics, Hepatitis C/virology, Host-Pathogen Interactions, Humans, Odds Ratio, Phenotype, Polymorphism, Single Nucleotide, Receptors, KIR/genetics, Sustained Virologic Response, Treatment Outcome, hepatitis C, host genetics, spontaneous clearance, sustained virological response
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/03/2017 11:59
Dernière modification de la notice
20/08/2019 16:47
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