A systematic review and meta-analysis of HCV clearance.
Details
Serval ID
serval:BIB_CC51EE2DCFF5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A systematic review and meta-analysis of HCV clearance.
Journal
Liver international
Working group(s)
Swiss Hepatitis C Cohort Study
ISSN
1478-3231 (Electronic)
ISSN-L
1478-3223
Publication state
Published
Issued date
10/2017
Peer-reviewed
Oui
Volume
37
Number
10
Pages
1431-1445
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
While hepatitis C exemplifies the role of host genetics in infectious diseases outcomes, there is no comprehensive overview of polymorphisms influencing spontaneous and/or treatment-induced hepatitis C virus clearance. We performed a systematic review and meta-analysis of host polymorphisms associated with these phenotypes. Literature search was conducted using combinations of keywords in three databases. Studies were reviewed and relevant data systematically extracted for subsequent meta-analyses. Polymorphisms from candidate gene studies were tested in two cohorts of HCV-infected patients with available genomic data. The literature search yielded 8'294 citations, among which 262 studies were selected. In the meta-analysis of 27 HLA studies, the most significant associations with spontaneous hepatitis C virus clearance included DQB1*02, DQB1*03, DRB1*04 and DRB1*11. In the meta-analysis of 16 studies of KIR genes and their HLA-ligands, KIR2DS3 was associated with both spontaneous and treatment-induced clearance, and the HLA-C2 ligand with failure to spontaneously clear the virus. In a pooled analysis of 105 candidate genes and two genome-wide association studies, we observed associations of single nucleotide polymorphisms from nine genes (EIF2AK2, IFNAR2, ITPA, MBL2, MX1, OASL, SPP1, TGFB1, TNK2) with response to interferon-based therapy. Meta-analysis of 141 studies confirmed the association of IFNL3/4 polymorphisms with spontaneous and treatment-induced hepatitis C virus clearance, even in previously underpowered groups, such as hepatitis C virus genotypes 2/3-infected patients. This study may contribute to a better understanding of hepatitis C virus immunopathogenesis and highlights the complex role of host genetics in hepatitis C virus clearance.
Keywords
Antiviral Agents/therapeutic use, Genotype, HLA Antigens/genetics, Hepacivirus/drug effects, Hepacivirus/genetics, Hepacivirus/pathogenicity, Hepatitis C/diagnosis, Hepatitis C/drug therapy, Hepatitis C/genetics, Hepatitis C/virology, Host-Pathogen Interactions, Humans, Odds Ratio, Phenotype, Polymorphism, Single Nucleotide, Receptors, KIR/genetics, Sustained Virologic Response, Treatment Outcome, hepatitis C, host genetics, spontaneous clearance, sustained virological response
Pubmed
Web of science
Open Access
Yes
Create date
14/03/2017 11:59
Last modification date
20/08/2019 16:47