The gasdermins, a protein family executing cell death and inflammation.

Détails

Ressource 1Télécharger: NRI The Gasdermins_accepted.pdf (3434.48 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
Document(s) secondaire(s)
Télécharger: Supporting file.pdf (966.16 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_CBCAA3D61F5E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The gasdermins, a protein family executing cell death and inflammation.
Périodique
Nature reviews. Immunology
Auteur(s)
Broz P. (co-dernier), Pelegrín P. (co-dernier), Shao F. (co-dernier)
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Statut éditorial
Publié
Date de publication
03/2020
Peer-reviewed
Oui
Volume
20
Numéro
3
Pages
143-157
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The gasdermins are a family of recently identified pore-forming effector proteins that cause membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell death. Gasdermins contain a cytotoxic N-terminal domain and a C-terminal repressor domain connected by a flexible linker. Proteolytic cleavage between these two domains releases the intramolecular inhibition on the cytotoxic domain, allowing it to insert into cell membranes and form large oligomeric pores, which disrupts ion homeostasis and induces cell death. Gasdermin-induced pyroptosis plays a prominent role in many hereditary diseases and (auto)inflammatory disorders as well as in cancer. In this Review, we discuss recent developments in gasdermin research with a focus on mechanisms that control gasdermin activation, pore formation and functional consequences of gasdermin-induced membrane permeabilization.
Mots-clé
Cell Death/physiology, Cell Membrane/metabolism, Cell Membrane Permeability/physiology, Humans, Inflammation/metabolism, Neoplasm Proteins/metabolism, Pyroptosis/physiology
Pubmed
Web of science
Création de la notice
07/11/2019 23:32
Dernière modification de la notice
17/04/2021 6:33
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