The gasdermins, a protein family executing cell death and inflammation.

Details

Serval ID
serval:BIB_CBCAA3D61F5E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The gasdermins, a protein family executing cell death and inflammation.
Journal
Nature reviews. Immunology
Author(s)
Broz P., Pelegrín P., Shao F.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Publication state
Published
Issued date
03/2020
Peer-reviewed
Oui
Volume
20
Number
3
Pages
143-157
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The gasdermins are a family of recently identified pore-forming effector proteins that cause membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell death. Gasdermins contain a cytotoxic N-terminal domain and a C-terminal repressor domain connected by a flexible linker. Proteolytic cleavage between these two domains releases the intramolecular inhibition on the cytotoxic domain, allowing it to insert into cell membranes and form large oligomeric pores, which disrupts ion homeostasis and induces cell death. Gasdermin-induced pyroptosis plays a prominent role in many hereditary diseases and (auto)inflammatory disorders as well as in cancer. In this Review, we discuss recent developments in gasdermin research with a focus on mechanisms that control gasdermin activation, pore formation and functional consequences of gasdermin-induced membrane permeabilization.
Keywords
Cell Death/physiology, Cell Membrane/metabolism, Cell Membrane Permeability/physiology, Humans, Inflammation/metabolism, Neoplasm Proteins/metabolism, Pyroptosis/physiology
Pubmed
Web of science
Create date
07/11/2019 23:32
Last modification date
19/06/2020 6:21
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